From genotype & transcriptome to phenotype

Next to phenotyping, we also perform genotypic and transcriptomic analyses. We use multiplex amplicon sequencing to identify which genes are successfully edited and what their exact edit pattern is. This allows us to trace back through data analysis which edits are responsible for which phenotypes. 

Next to genotypic information we also harness transcriptomic data to identify the effects of specific mutations on the gene regulatory networks. The transcriptome helps us explain how exactly a mutation influences a certain phenotype.